Skin Manifestations of Inflammatory Bowel Disease
نویسندگان
چکیده
Inflammatory bowel disease (IBD) is a disease that affects the intestinal tract via an inflammatory process. Patients who suffer from IBD often have diseases that affect multiple other organ systems as well. These are called extraintestinal manifestations and can be just as, if not more debilitating than the intestinal inflammation itself. The skin is one of the most commonly affected organ systems in patients who suffer from IBD. The scientific literature suggests that a disturbance of the equilibrium between host defense and tolerance, and the subsequent over-activity of certain immune pathways are responsible for the cutaneous disorders seen so frequently in IBD patients. The purpose of this review article is to give an overview of the types of skin diseases that are typically seen with IBD and their respective pathogenesis, proposed mechanisms, and treatments. These cutaneous disorders can manifest as metastatic lesions, reactive processes to the intestinal inflammation, complications of IBD itself, or side effects from IBD treatments; these can be associated with IBD via genetic linkage, common autoimmune processes, or other mechanisms that will be discussed in this article. Ultimately, it is important for healthcare providers to understand that skin manifestations should always be checked and evaluated for in patients with IBD. Furthermore, skin disorders can predate gastrointestinal symptoms and thus may serve as important clinical indicators leading physicians to earlier diagnosis of IBD.
منابع مشابه
Concomitant occurrence of pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease.
Erythema nodosum and pyoderma gangrenosum are common skin manifestations in inflammatory bowel diseases. Curiously, these two cutaneous features have seldom been reported to occur simultaneously. We present three patients affected with inflammatory bowel disease with concomitant erythema nodosum and pyoderma gangrenosum.
متن کاملSweet Syndrome Accompanying Inflammatory Bowel Disease in a Child
Acute neutrophilic dermatosis, first described in 1964 by Robert Douglas Sweet, is characterized by sudden onset fever, neutrophilic leukocytosis, and well demarcated erythematous papules, nodules, and plaques with dense neutrophilic infiltrates on histologic evaluation.Here is a report of a 7-year-old girl who presented with high grade fever, and discrete erythematous papular skin eruptions, w...
متن کاملCase for diagnosis. Metastatic Crohn's disease*
Metastatic Crohn's disease is a rare skin manifestation, defined by granulomatous skin lesions that are discontinuous to the affected gastrointestinal tract and histopathologically resembling inflammatory bowel lesions. Up to 44% of patients with Crohn's disease have cutaneous manifestations, of which metastatic lesions are the least common. We present a case of an adolescent with refractory Cr...
متن کاملA brief account of the pathology and pathogenesis of the cutaneous manifestations of Crohns disease
Inflammatory Bowel Disease (IBD) is a lifelong condition, which may occur in patients of any age. Prior to confirming a diagnosis of IBD, clinicians may face unusual non gastrointestinal symptoms. The extra intestinal manifestations of Crohn's disease (CD) may develop prior to signs of gastrointestinal involvement. Many of these extraintestinal clinical signs overlap with those seen in patients...
متن کاملSkin gangrene as an extraintestinal manifestation of inflammatory bowel disease*
Inflammatory bowel diseases can commonly present many cutaneous lesions which can contribute to the diagnosis of the disease or its activity. The most frequent cutaneous or mucocutaneous manifestations suggesting ulcerative rectocolitis activity are erythema nodosum (3-10%), pyoderma gangrenosum (5-12%) and aphthous stomatitis (4%). Other reactive skin manifestations related to immunological me...
متن کاملErythema nodosum as a presentation of inflammatory bowel disease.
T case was notable because the initial presentation of Crohn’s disease consisted only of extraintestinal manifestations. This is uncommon, and the vast majority of children will present with the typical combination of abdominal pain, diarrhea and weight loss with or without extraintestinal manifestations (Box 1). Extraintestinal manifestations occur in about 25%–35% of cases of inflammatory bow...
متن کامل